Rare and novel RELA variants are common in systemic autoimmunity
Morgan B. Downes, Sonia B. Nambadan, Joanne Chow, Ainsley R. Davies, Gemma Hart, T. Daniel Andrews, Nicole Lehmann, Isabella Bales, Alamelu Vengatasalam, Arthur Richard Kitching, Carolyn A. Hawkins, Ted Tsai, Chandima Perera, Giles Desmond Walters, Vicki Athanasopoulos, Simon Jiang
The paper identifies rare RELA variants in autoimmune diseases and shows they affect NF-κB and IFNβ transcriptional activity and immune cell subsets.
Arthritis & Rheumatology · Dec 26, 2025Peer-reviewedImmunology