Simon Jiang

This paper generates a novel Slc7a9G105R mouse model to study cystinuria, identifying new biomarkers and therapeutic insights.

The paper identifies rare RELA variants in autoimmune diseases and shows they affect NF-κB and IFNβ transcriptional activity and immune cell subsets.

RISER enables real-time RNA class enrichment or depletion during direct RNA sequencing, improving detection of low-abundance RNAs by reducing dominant RNA reads.

This study uses nanopore adaptive sampling to profile age and body fluid DNA methylation markers, identifying new age-correlated sites and validating known markers.