NeurosciencebioRxivPreprint
Genetic inactivation of the USP19 deubiquitinase regulates a-synuclein ubiquitination and inhibits accumulation of Lewy body like aggregates in mice
Lenka Schorova, Nathalie Bedard, Anouar Khayachi…·Simon S. Wing
This study shows that genetic inactivation of USP19 reduces a-synuclein ubiquitination and Lewy body-like aggregate accumulation in a mouse model of Parkinson's disease.
DOI 10.1101/2022.12.21.521125