Author

Lenka Schorova

Research Institute of the McGill University Health Centre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

Anouar KhayachiiD· 3 shared Anusha KameshiD· 2 shared Austen J. MilnerwoodiD· 2 shared Boris ChaumetteiD· 2 shared Guy Armand RouleauiD· 2 shared Martin AldaiD· 2 shared Alessia PietrantonioiD· 1 shared Ariel R. Ase· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersNeuroscience

Anouar KhayachiORCID

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3 papers

Recent·Most cited

Molecular signatures of hyperexcitability and lithium responsiveness in bipolar disorder patient neurons provide alternative therapeutic strategies.

Anouar Khayachi, Malak Abuzgaya, Yumin Liu, Chuan Jiao, Kurt Dejgaard, Lenka Schorova, Anusha Kamesh, Qin He, Yuting Cousineau, Alessia Pietrantonio, Nargess Farhangdoost, Charles-Etienne Castonguay, Boris Chaumette, Martin Alda, Guy Armand Rouleau, Austen J. Milnerwood

The paper identifies molecular signatures of neuronal hyperexcitability and lithium responsiveness in bipolar disorder neurons, suggesting new therapeutic strategies targeting Akt and AMPK pathways.

EBioMedicine · May 20, 2024Peer-reviewedNeuroscience

Genetic inactivation of the USP19 deubiquitinase regulates a-synuclein ubiquitination and inhibits accumulation of Lewy body like aggregates in mice

Lenka Schorova, Nathalie Bedard, Anouar Khayachi, Joao Bolivar-Pedroso, Hung-Hsiang Ho, Julie Huynh, Mikaela Piccirelli, Yifei Wang, Marie Plourde, Wen Luo, Esther del Cid‐Pellitero, Irina Shlaifer, Yihong Ye, Thomas M. Durcan, Simon S. Wing

This study shows that genetic inactivation of USP19 reduces a-synuclein ubiquitination and Lewy body-like aggregate accumulation in a mouse model of Parkinson's disease.

bioRxiv · Dec 21, 2022 · PreprintNeuroscience

Chronic lithium treatment alters the excitatory/inhibitory balance of synaptic networks and reduces mGluR5-PKC signaling

Anouar Khayachi, Ariel R. Ase, Calwing Liao, Anusha Kamesh, Naila Kuhlmann, Lenka Schorova, Boris Chaumette, Patrick A. Dion, Martin Alda, Philippe Séguéla, Guy Armand Rouleau, Austen J. Milnerwood

This study shows chronic lithium treatment reduces neuronal excitability and shifts the excitatory/inhibitory balance toward inhibition in mouse cortical neurons.

Journal of Psychiatry and Neuroscience · May 1, 2021Peer-reviewedNeuroscience