Genetic inactivation of the USP19 deubiquitinase regulates a-synuclein ubiquitination and inhibits accumulation of Lewy body like aggregates in mice
Lenka Schorova, Nathalie Bedard, Anouar Khayachi, Joao Bolivar-Pedroso, Hung-Hsiang Ho, Julie Huynh, Mikaela Piccirelli, Yifei Wang, Marie Plourde, Wen Luo, Esther del Cid‐Pellitero, Irina Shlaifer, Yihong Ye, Thomas M. Durcan, Simon S. Wing
This study shows that genetic inactivation of USP19 reduces a-synuclein ubiquitination and Lewy body-like aggregate accumulation in a mouse model of Parkinson's disease.
bioRxiv · Dec 21, 2022 · PreprintNeuroscience