Posttranslational modifications of the DUX4 protein impact toxic function
Renatta N. Knox, Jocelyn O. Eidahl, Lindsay M. Wallace, Sarah G. Choudury, Afrooz Rashnonejad, Nizar Y. Saad, Michael E. Hoover, Liwen Zhang, Owen E. Branson, Michael A. Freitas, Scott Q. Harper
This study identifies posttranslational modifications of DUX4 that regulate its toxic function in FSHD and suggests potential therapeutic targets.
bioRxiv · Jul 22, 2022 · PreprintNeuroscience