Author

Michael A. Freitas

The Ohio State UniversityORCID 0000-0002-3103-8410Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Biochemistry· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:ChIP-seq· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Benjamin D. SunkeliD· 2 shared Benjamin Z. StantoniD· 2 shared Callie M. Lovejoy· 2 shared Liudmila V. PopovaiD· 2 shared Mark R. ParthuniD· 2 shared Miranda L. GardneriD· 2 shared Prabakaran NagarajaniD· 2 shared Afrooz RashnonejadiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Benjamin D. SunkelORCID

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Author profile →

5 papers

Recent·Most cited

Hat1 Orchestrates Heterochromatin Inheritance by Regulating Localization of H3K9 Methyltransferases

Caden J. Martin, Liudmila V. Popova, Prabakaran Nagarajan, Elizabeth A. Oser, Callie M. Lovejoy, Benjamin D. Sunkel, Benjamin Z. Stanton, Michael A. Freitas, Mark R. Parthun

This study shows Hat1 regulates H3K9 methylation and HMT localization in LADs, affecting heterochromatin structure and inheritance in mouse cells.

bioRxiv · Mar 23, 2026 · PreprintBiochemistry

Posttranslational modifications of the DUX4 protein impact toxic function

Renatta N. Knox, Jocelyn O. Eidahl, Lindsay M. Wallace, Sarah G. Choudury, Afrooz Rashnonejad, Nizar Y. Saad, Michael E. Hoover, Liwen Zhang, Owen E. Branson, Michael A. Freitas, Scott Q. Harper

This study identifies posttranslational modifications of DUX4 that regulate its toxic function in FSHD and suggests potential therapeutic targets.

bioRxiv · Jul 22, 2022 · PreprintNeuroscience

TIMSCONVERT: A workflow to convert trapped ion mobility data to open data formats

Gordon T. Luu, Michael A. Freitas, Itzel Lizama-Chamu, Catherine S. McCaughey, Laura M. Sanchez, Mingxun Wang

TIMSCONVERT converts trapped ion mobility data to open formats for compatibility with downstream analysis tools.

Bioinformatics · Jun 27, 2022Peer-reviewedBioinformatics

Epigenetic Regulation of Nuclear Lamina-Associated Heterochromatin by HAT1 and the Acetylation of Newly Synthesized Histones

Liudmila V. Popova, Prabakaran Nagarajan, Callie M. Lovejoy, Benjamin D. Sunkel, Miranda L. Gardner, Meng Wang, Michael A. Freitas, Benjamin Z. Stanton, Mark R. Parthun

This study shows HAT1 acetylates new histones during DNA replication, regulating chromatin state inheritance and nuclear lamina-heterochromatin interactions.

Nucleic Acids Research · Oct 15, 2021Peer-reviewedGenomics

Multiple Imputation Approaches Applied to the Missing Value Problem in Bottom-up Proteomics

Miranda L. Gardner, Michael A. Freitas

This paper evaluates missing value imputation strategies in proteomics, advocating for hybrid left-censored approaches to handle missing not at random data.

International Journal of Molecular Sciences · Sep 6, 2021Peer-reviewedBioinformatics