Author

Afrooz Rashnonejad

Nationwide Children's HospitalORCID 0000-0002-0198-5492Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Nizar Y. SaadiD· 2 shared Scott Q. HarperiD· 2 shared Allison M. BradburyiD· 1 shared Allison M. Fowler· 1 shared Ben Kelly· 1 shared Burçak ÖzeşiD· 1 shared Colin T. MaguireiD· 1 shared Devi Jaganathan· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenetics

Nizar Y. SaadORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintMay 29, 2025

REMEDY: REpair of heterozygous Mutations independent of Exogenous Donor template with high efficiency using allele specific CRISPR targeting and HDR enhancers

Yasemin Sezgin, Genesis Snyder, Noushin Saljoughian…·Meisam Naeimi Kararoudi

REMEDY enables efficient repair of heterozygous mutations in human and mouse cells without exogenous donor DNA by using CRISPR-induced DSBs and HDR enhancers.

DOI 10.1101/2025.05.29.641201

humanmouse

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Molecular BiologybioRxivPreprintDec 18, 2024

Sustained efficacy of CRISPR-Cas13b gene therapy for FSHD is challenged by immune response to Cas13b

Afrooz Rashnonejad, Manal Farea, Gholamhossein Amini Chermahini…·Scott Q. Harper

This study shows CRISPR-Cas13b effectively reduces DUX4 in FSHD but is limited by immune responses that decrease Cas13b levels over time.

4 citations

mousehuman

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NeurosciencebioRxivPreprintJul 22, 2022

Posttranslational modifications of the DUX4 protein impact toxic function

Renatta N. Knox, Jocelyn O. Eidahl, Lindsay M. Wallace…·Scott Q. Harper

This study identifies posttranslational modifications of DUX4 that regulate its toxic function in FSHD and suggests potential therapeutic targets.

DOI 10.1101/2022.07.22.501148

humanexperimental assay

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