A targetable dependency on nonsense-mediated decay for proteostasis and immune control in small cell lung cancer
Lucia Torres Fernández, Volker Boehm, Joel Kaufmann, Agnieszka Rumińska, Jonas Philipp Becker, María García Márquez, Beaunelle de Bruijn, Christian Müller, Nazanin Alavinejad, Laura Lovric, Johanna I. Bihler, Kian R. Weihrauch, Laura Kaiser, Marcel Schmiel, Lukas Maas, , Julie George
This study identifies NMD inhibition as a therapeutic strategy for SCLC by enhancing immunogenicity and improving immunotherapy efficacy through increased neoantigen presentation.
bioRxiv · Apr 2, 2026 · PreprintCancer Biology