Volker Boehm

This study identifies NMD inhibition as a therapeutic strategy for SCLC by enhancing immunogenicity and improving immunotherapy efficacy through increased neoantigen presentation.

This study rapidly depletes UPF1 in human cells to investigate NMD-regulated transcriptome dynamics, identifying core transcripts and biological processes affected.

This study identifies interactions between SARS-CoV-2 N-protein and NMD factors, showing N inhibits UPF1 activity and may stabilize viral RNA.

The paper introduces NMDtxDB, a database of human NMD target transcripts identified through a data-driven approach using transcriptome assembly and NMD activity comparisons.

The paper investigates the role of SMG8 and SMG9 in maintaining NMD robustness by analyzing transcriptome-wide changes and UPF1 interactome in human cells with genetic modifications.

The paper shows that bacterial pore-forming toxins induce alternative splicing of CIRBP and SRSFs, altering cell response to Listeria infection.

This study shows that CMTR1-mediated N1-2'O-methylation prevents antiviral recognition and regulates NVL2 mRNA splicing, affecting cell size, division, and ribosome biogenesis.

The paper investigates the role of RNPS1 in splicing regulation and NMD by analyzing transcriptome-wide effects of its knockdowns, finding that RNPS1 primarily regulates splicing through distinct domains and interacts with splicing factors.

This study shows that UPF3A and UPF3B redundantly activate nonsense-mediated mRNA decay in human cells, with their combined depletion inhibiting NMD and upregulating substrates.

Baltica integrates results from multiple differential junction usage methods to improve splicing analysis, showing JunctionSeq performs best and meta-classifiers outperform single-method classifiers.

The paper reveals that SMG5-SMG7 and SMG6 work in a coordinated, hierarchical manner in NMD, with SMG5-SMG7 enabling SMG6 activity through UPF1 phosphorylation and heterodimer formation.

ScNapBar enables accurate cell barcode assignment for Nanopore single cell RNA sequencing by combining UMI and Naive Bayes approaches, distinguishing cell populations with active or silenced nonsense-mediated decay.

This study shows that CASC3 enhances NMD by linking the EJC to the NMD machinery, leading to increased degradation of NMD-targeted mRNAs.