Human interferon stimulated genes target ancient features of animal and bacterial viral replication
Samantha G. Fernandez, Jill E. Hutchinson, Joel MJ Tan, Sonomi Yamaguchi, Anne A. Roffler, Aaron G. Schmidt, Philip J. Kranzusch
The paper shows human ISGs can restrict bacterial phage replication, revealing conserved antiviral mechanisms across kingdoms.
bioRxiv · Jun 12, 2026 · PreprintImmunology