Author

Sonomi Yamaguchi

Harvard UniversityORCID 0000-0002-5562-8044Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Philip J. KranzuschiD· 2 shared Samantha G. FernandeziD· 2 shared Aaron G. SchmidtiD· 1 shared Anne A. RoffleriD· 1 shared Douglas R. WassarmaniD· 1 shared Frank SchwedeiD· 1 shared Jill E. Hutchinson· 1 shared Joel MJ Tan· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

Philip J. KranzuschORCID

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2 papers

Recent·Most cited

Human interferon stimulated genes target ancient features of animal and bacterial viral replication

Samantha G. Fernandez, Jill E. Hutchinson, Joel MJ Tan, Sonomi Yamaguchi, Anne A. Roffler, Aaron G. Schmidt, Philip J. Kranzusch

The paper shows human ISGs can restrict bacterial phage replication, revealing conserved antiviral mechanisms across kingdoms.

bioRxiv · Jun 12, 2026 · PreprintImmunology

Activating and inhibiting nucleotide signals coordinate bacterial anti-phage defense

Sonomi Yamaguchi, Samantha G. Fernandez, Douglas R. Wassarman, Marlen Lüders, Frank Schwede, Philip J. Kranzusch

This study identifies a bacterial anti-phage defense system, Clover, which uses nucleotide signals to dynamically regulate antiviral immunity while avoiding cellular toxicity.

Nature · Feb 18, 2026Peer-reviewedMicrobiology