Predicting and Controlling Collective Fate in Multicellular Systems
Tiam Heydari, Omar S. Bashth, Joelle Fernandes, Bhavya Sabbineni, Daniel Aguilar‐Hidalgo, Jessica Chen, Nika Shakiba, Leah Edelstein-keshet A, Peter W. Zandstra
The paper develops a framework to predict and control collective fate in multicellular systems by identifying a control regime where a single guide cell can redirect tissue-level organization.
bioRxiv · Dec 15, 2025 · PreprintSystems Biology