Functional, transcriptomic, and proteomic profiles of human primary and stem cell-derived beta cells in a state of high insulin production and increased fragility
Chieh Min Jamie Chu, Meltem E. Omur, Jasmine Maghera, Haoning Howard Cen, Alyssa M. Weinrauch, Sing-Young Chen, Luo Ting Helen Huang, Renata Moravcova, Jason C. Rogalski, Bhavya Sabbineni, Niki Shahraki, Samantha Mar, Cara E. Ellis, Wyeth W. Wasserman, Patrick E. MacDonald, , James D. Johnson
This study compares functional, transcriptomic, and proteomic profiles of human primary and stem cell-derived beta cells in high and low insulin production states, revealing differences in resilience and protein machinery.
bioRxiv · Aug 19, 2026 · PreprintPhysiology