Daniel Aguilar‐Hidalgo

The paper develops a framework to predict and control collective fate in multicellular systems by identifying a control regime where a single guide cell can redirect tissue-level organization.

The paper uses a computational model and experiments to show that small micro-patterned mPSC colonies exhibit spontaneous asymmetry in BRA-GFP patterns, suggesting a mechanism for symmetry-breaking in development.

The paper develops a GRN model embedded in cellular agents to simulate hPSC lineage commitment and shows how GRN wiring influences germ layer pattern formation.

IQCELL predicts gene perturbation effects on developmental trajectories using scRNA-seq data, showing it can infer over 75% of known causal gene interactions in mouse T-cell development.

The paper identifies a small peptide, pegasus, that enhances Wg diffusion during Drosophila wing development, contributing to proper wing margin formation.

The paper develops an in vitro platform to study fate patterning in hPSCs, revealing Nodal-dependent switches between gastrulation and neurulation-associated gene profiles.