Expanding the scope of bacterial CRISPR activation with PAM-flexible dCas9 variants
Cholpisit Kiattisewee, Ava V. Karanjia, Mateusz Legut, Zharko Daniloski, Samantha E. Koplik, Joely Nelson, Benjamin P. Kleinstiver, Neville E. Sanjana, James M. Carothers, Jesse G. Zalatan
This study evaluates PAM-flexible dCas9 variants for bacterial CRISPR activation and repression, finding trade-offs between PAM flexibility and repression efficiency.
ACS Synthetic Biology · Nov 15, 2022Peer-reviewedSynthetic Biology