Author

Samantha E. Koplik

University of WashingtonORCID 0000-0003-3614-4885Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Assay:CRISPR screen· 2 Organism:bacteria (other)· 1 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Alex K. Sabo· 1 shared Alexander B. RosenbergiD· 1 shared Alexandra M. Piñeiro· 1 shared Angela M YuiD· 1 shared Ava V. KaranjiaiD· 1 shared Benjamin H. WeinbergiD· 1 shared Benjamin P. KleinstiveriD· 1 shared Charles M. RocoiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperSynthetic Biology

Alex K. Sabo

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintOct 12, 2025

Massively parallel assay of human splice variants reveals cis-regulatory drivers of disease-associated and cell type-specific splicing regulation

Samantha E. Koplik, Angela M Yu, Madelyn R. Shelby…·Georg Seelig

The paper develops COMPASS, a method to assess splicing variant effects across cell types, identifying disease-associated variants and cell type-specific splicing programs.

1 citation

humanspatial transcriptomics

𝕏 PostBluesky

Synthetic BiologyACS Synthetic BiologyPeer-reviewedNov 15, 2022

Expanding the scope of bacterial CRISPR activation with PAM-flexible dCas9 variants

Cholpisit Kiattisewee, Ava V. Karanjia, Mateusz Legut…·Jesse G. Zalatan

This study evaluates PAM-flexible dCas9 variants for bacterial CRISPR activation and repression, finding trade-offs between PAM flexibility and repression efficiency.

20 citations

bacteria (other)CRISPR screen

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Synthetic BiologybioRxivPreprintJun 7, 2022

Programmable Mixed-Signal Biocomputers in Mammalian Cells

Justin H. Letendre, Benjamin H. Weinberg, Marisa Mendes…·Wilson W. Wong

This paper introduces CREATE, a genetic circuit platform that enables complex signal processing in mammalian cells through programmable transcription factors and site-specific recombination.

3 citations

mouseexperimental assay

𝕏 PostBluesky