Cancer BiologybioRxivPreprint
Dissecting the oncogenic mechanisms of POT1 cancer mutations through deep scanning mutagenesis
Annika Martin, Johannes J. Schabort, Rebecca Bartke-Croughan…·Dirk F. Hockemeyer
This study uses deep scanning mutagenesis to analyze POT1 mutations in human stem cells, revealing that some cancer-associated variants drive telomere elongation and oncogenesis independently of telomere replication.
DOI 10.1101/2024.08.19.608636