Dissecting the oncogenic mechanisms of POT1 cancer mutations through deep scanning mutagenesis
Annika Martin, Johannes J. Schabort, Rebecca Bartke-Croughan, Stella Tran, Atul Preetham, Robert Lu, Richard Ho, Jianpu Gao, Shirin S Jenkins, John Boyle, George E. Ghanim, Milind Jagota, Yun S. Song, Hanqin Li, Dirk F. Hockemeyer
This study uses deep scanning mutagenesis to analyze POT1 mutations in human stem cells, revealing that some cancer-associated variants drive telomere elongation and oncogenesis independently of telomere replication.
bioRxiv · Aug 19, 2024 · PreprintCancer Biology