Author

George E. Ghanim

MRC Laboratory of Molecular BiologyORCID 0000-0002-3341-3122Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Annika MartiniD· 1 shared Atul Preetham· 1 shared Dirk F. HockemeyeriD· 1 shared Donald C. RioiD· 1 shared Hanqin LiiD· 1 shared Jianpu GaoiD· 1 shared Johannes J. Schabort· 1 shared John Boyle· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Annika MartinORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Dissecting the oncogenic mechanisms of POT1 cancer mutations through deep scanning mutagenesis

Annika Martin, Johannes J. Schabort, Rebecca Bartke-Croughan, Stella Tran, Atul Preetham, Robert Lu, Richard Ho, Jianpu Gao, Shirin S Jenkins, John Boyle, George E. Ghanim, Milind Jagota, Yun S. Song, Hanqin Li, Dirk F. Hockemeyer

This study uses deep scanning mutagenesis to analyze POT1 mutations in human stem cells, revealing that some cancer-associated variants drive telomere elongation and oncogenesis independently of telomere replication.

bioRxiv · Aug 19, 2024 · PreprintCancer Biology

Activity of zebrafish THAP9 transposase and zebrafish P element-like transposons

Nitzan Kutnowski, George E. Ghanim, Yeon Ji Lee, Donald C. Rio

This study identifies an active zebrafish THAP9 transposase that can excise its own Pdre elements and Drosophila P elements, but not transpose them, revealing distinct DNA binding preferences.

bioRxiv · Mar 22, 2024 · PreprintBiochemistry