AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone
Assmaa ElSheikh, Camden M. Driggers, Ha H. Truong, Zhongying Yang, John Allen, Niel M. Henriksen, Katarzyna Walczewska-Szewc, Show‐Ling Shyng
The paper identifies a novel KATP channel pharmacochaperone, Aekatperone, using AI screening and cryoEM, showing reversible inhibition and functional recovery of trafficking mutants.
eLife · Mar 26, 2025Peer-reviewedBiochemistry