Author

Assmaa ElSheikh

Oregon Health & Science UniversityORCID 0000-0001-7360-9309Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:diffusion model· 1 Assay:electrophysiology· 1 Assay:imaging· 1

Frequent Co-Authors

Show‐Ling ShyngiD· 2 shared Camden M. DriggersiD· 1 shared Charles A. StanleyiD· 1 shared Colin Daniel· 1 shared David A. BakeriD· 1 shared Diva D. De LeóniD· 1 shared Ha H. Truong· 1 shared John Allen· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 22, 2026

✦ In-depth digest

MYC targeted de novo binders impair tumor growth

Nora K. McNamara-Bordewick, Kejia Wu, Yulong Su…·David A. Baker

Designed protein binders to conserved MYC regions reach low-nanomolar affinity, reduce MYC-MAX proximity in cells, and are depleted from MYC-dependent cancer cells in culture and mouse pancreatic tumors.

1 citation

humanmouse

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BiochemistryJournal of Biological ChemistryPeer-reviewedSep 27, 2025

Identification and Rescue of Congenital Hyperinsulinism-Associated ABCC8 Mutations that Impair KATP Channel Trafficking

Assmaa ElSheikh, Yi‐Ying Kuo, Kara E. Boodhansingh…·Show‐Ling Shyng

The paper identifies seven new SUR1 mutations in HI patients that impair KATP channel trafficking and function, showing varied responses to pharmacochaperone rescue.

3 citations

humanelectrophysiology

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BiochemistryeLifePeer-reviewedMar 26, 2025

AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone

Assmaa ElSheikh, Camden M. Driggers, Ha H. Truong…·Show‐Ling Shyng

The paper identifies a novel KATP channel pharmacochaperone, Aekatperone, using AI screening and cryoEM, showing reversible inhibition and functional recovery of trafficking mutants.

DOI 10.7554/elife.103159.3

humanstructural biology

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