Structural characterization of two full length γδTCR/CD3 complexes
Mohammed Hoque, John Benji Grigg, Trudy F. Ramlall, Jennifer L. Jones, Luke L. McGoldrick, John C. Lin, William C. Olson, Eric Smith, Matthew C. Franklin, Tong Zhang, Kei Saotome
This study reports cryoEM structures of two full-length γδ TCR/CD3 complexes, revealing similarities to β TCRs but with highly mobile extracellular domains and a dimeric assembly in one complex.
Nature Communications · Jan 2, 2025Peer-reviewedBiochemistry