Author

Luke L. McGoldrick

Regeneron (United States)ORCID 0000-0002-8310-7502Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Matthew C. FrankliniD· 3 shared Trudy F. Ramlall· 3 shared William C. OlsoniD· 3 shared Jennifer L. JonesiD· 2 shared Kei SaotomeiD· 2 shared Raymond Leidich· 2 shared Annan SI CookiD· 1 shared Eric SmithiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBiochemistry

Matthew C. FranklinORCID

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3 papers

Recent·Most cited

Structural basis for constitutive activation of oncogenic gp130 mutants in human inflammatory hepatocellular adenomas

Yi Zhou, Jing Cao, Trudy F. Ramlall, Luke L. McGoldrick, Jennifer L. Jones, Annan SI Cook, Raymond Leidich, Mark W. Sleeman, William C. Olson, Panayiotis E. Stevis, Matthew C. Franklin

This study identifies structural mechanisms of gp130 mutant activation in IHCAs using cryo-EM and mutagenesis, revealing two distinct dimer conformations and their activation dependencies.

bioRxiv · Nov 11, 2025 · PreprintBiochemistry

Structural characterization of two full length γδTCR/CD3 complexes

Mohammed Hoque, John Benji Grigg, Trudy F. Ramlall, Jennifer L. Jones, Luke L. McGoldrick, John C. Lin, William C. Olson, Eric Smith, Matthew C. Franklin, Tong Zhang, Kei Saotome

This study reports cryoEM structures of two full-length γδ TCR/CD3 complexes, revealing similarities to β TCRs but with highly mobile extracellular domains and a dimeric assembly in one complex.

Nature Communications · Jan 2, 2025Peer-reviewedBiochemistry

Structural insights into CXCR4 modulation and oligomerization

Kei Saotome, Luke L. McGoldrick, Jo-Hao Ho, Trudy F. Ramlall, Sweta Shah, Michael J. Moore, Jee Hae Kim, Raymond Leidich, William C. Olson, Matthew C. Franklin

This study uses cryoEM to reveal structural details of CXCR4 activation by CXCL12 and its oligomerization, showing new modes of GPCR regulation.

Nature Structural & Molecular Biology · Sep 23, 2024Peer-reviewedBiochemistry