Author

Kei Saotome

Regeneron (United States)ORCID 0000-0002-4135-5356Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 4 Approach:experimental assay· 4 Research Focus:protein structure prediction· 3 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Matthew C. FrankliniD· 3 shared Luke L. McGoldrickiD· 2 shared Mohammed HoqueiD· 2 shared Tong ZhangiD· 2 shared Trudy F. Ramlall· 2 shared William C. OlsoniD· 2 shared Anbo ZhouiD· 1 shared Andrew D Baik· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Matthew C. FranklinORCID

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Author profile →

4 papers

Recent·Most cited

Bacterial major vault protein homologs form divergent vault structures

Jake C Lachowicz, Mohammed Hoque, Anbo Zhou, Tong Zhang, Matthew C Franklin, Richard Copin, Katherine D Cygnar, Andrew J Murphy, Kei Saotome, Andrew D Baik

The paper identifies bacterial MVP homologs and reports cryoEM structures of vaults from Corallococcus praedator and a Deltaproteobacteria bacterium, revealing novel symmetries.

bioRxiv · Nov 9, 2026 · PreprintBiochemistry

CryoEM structure of ALK2:BMP6 reveals distinct mechanisms that allow ALK2 to interact with both BMP and Activin ligands

Erich J. Goebel, Senem Aykul, Warren W. Hom, Kei Saotome, Aris N. Economides, Matthew C. Franklin, Vincent J. Idone

This paper presents the cryoEM structure of ALK2:BMP6, revealing distinct mechanisms for ALK2's interaction with BMP and activin ligands.

Proceedings of the National Academy of Sciences · Aug 25, 2025Peer-reviewedBiochemistry

Structural characterization of two full length γδTCR/CD3 complexes

Mohammed Hoque, John Benji Grigg, Trudy F. Ramlall, Jennifer L. Jones, Luke L. McGoldrick, John C. Lin, William C. Olson, Eric Smith, Matthew C. Franklin, Tong Zhang, Kei Saotome

This study reports cryoEM structures of two full-length γδ TCR/CD3 complexes, revealing similarities to β TCRs but with highly mobile extracellular domains and a dimeric assembly in one complex.

Nature Communications · Jan 2, 2025Peer-reviewedBiochemistry

Structural insights into CXCR4 modulation and oligomerization

Kei Saotome, Luke L. McGoldrick, Jo-Hao Ho, Trudy F. Ramlall, Sweta Shah, Michael J. Moore, Jee Hae Kim, Raymond Leidich, William C. Olson, Matthew C. Franklin

This study uses cryoEM to reveal structural details of CXCR4 activation by CXCL12 and its oligomerization, showing new modes of GPCR regulation.

Nature Structural & Molecular Biology · Sep 23, 2024Peer-reviewedBiochemistry