Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer
Eszter Lakatos, Vinaya Gunasri, Luis Zapata, Jacob Househam, Timon Heide, Nicholas Trahearn, Ottilie Swinyard, Luis Humberto Cisneros, Claire Lynn, Maximilian Mossner, Christopher Kimberley, Inmaculada Spiteri, Maurice P.H.M. Jansen, Manuel Rodriguez‐Justo, Miriam Mitchison, , Trevor A. Graham
This study shows that immune evasion in colorectal cancer follows a 'Big Bang' pattern, where early genetic and epigenetic changes drive subsequent tumor-immune evolution.
Nature Genetics · Jun 1, 2024Peer-reviewedCancer Biology