Luis Humberto Cisneros

This paper quantifies spatial cancer-stroma topology in post-TNT PDAC and shows it independently predicts disease-free survival better than traditional response assessments.

The paper introduces TLA, a computational framework using ecological principles to analyze tumor spatial heterogeneity and link it to clinical outcomes.

This study shows that immune evasion in colorectal cancer follows a 'Big Bang' pattern, where early genetic and epigenetic changes drive subsequent tumor-immune evolution.

This paper investigates adaptive therapy with single cytotoxic or cytostatic drugs, finding it effective under specific conditions and dosing strategies.

This paper evaluates adaptive therapy strategies using two cytotoxic or two cytostatic drugs, finding that dose modulation protocols perform better with cytotoxic drugs while ping-pong protocols are more effective with cytostatic drugs under specific conditions.