Jacob Househam

This study develops a neuroblastoma mouse model to investigate chemotherapy resistance and immune evasion mechanisms, identifying CDK8 upregulation and immune cell infiltration as key factors.

ProMPt is a syngeneic mouse platform modeling prostate cancer heterogeneity, revealing MYC's role in progression and showing that MAPK inhibition plus translation blockade synergistically suppresses castration-resistant tumors.

This paper identifies long deletion signatures in repetitive regions as markers of microsatellite instability and develops a classifier to detect MSI in low-quality sequencing data.

This study shows that immune evasion in colorectal cancer follows a 'Big Bang' pattern, where early genetic and epigenetic changes drive subsequent tumor-immune evolution.

The paper introduces rapidly oscillating molecular clocks to quantify human stem cell dynamics and finds differences in stem cell replacement rates between small intestine and colon, as well as effects of germline mutations.

This paper introduces CNAqc, a toolset for validating clonal and subclonal copy number alterations in bulk tumor sequencing by addressing tumor purity, ploidy, and heterogeneity using simulations and single-cell data.