DPP9 is an endogenous and direct inhibitor of the NLRP1 inflammasome that guards against human auto-inflammatory diseases
Franklin L. Zhong, Kim Robinson, Chrissie Lim, Cassandra R. Harapas, Chien-Hsiung Yu, William Xie, Radoslaw M. Sobota, Veonice Bijin Au, Richard Hopkins, John E. Connolly, Seth Masters, Bruno Reversade
This study identifies DPP9 as an endogenous inhibitor of the NLRP1 inflammasome, showing its role in preventing auto-inflammatory diseases through regulation of NLRP1 activity.
bioRxiv · Feb 7, 2018 · PreprintImmunology