Franklin L. Zhong

The paper identifies PP1 and PP2A phosphatases as regulators of NLRP1 inflammasome activation, showing that environmental toxins and viral infections trigger this pathway via TAK1 and p38 kinases.

This paper identifies two distinct MAP3K pathways activated by beetle toxins that trigger NLRP1 inflammasome activation in human keratinocytes.

This study investigates NLRP3 inflammasome activation in human keratinocytes, showing it is induced by IFN-gamma but not LPS, and that specific activators like Hla target NLRP3 while nigericin activates both NLRP1 and NLRP3.

This study identifies DPP9 deficiency as a Mendelian disorder causing inflammasome hyperactivity, which can be rescued by reducing NLRP1/IL-1 signaling in mice.

This study identifies DPP9 as an endogenous inhibitor of the NLRP1 inflammasome, showing its role in preventing auto-inflammatory diseases through regulation of NLRP1 activity.