Author

Cassandra R. Harapas

The University of MelbourneORCID 0000-0002-8875-4645Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Bruno ReversadeiD· 2 shared Franklin L. ZhongiD· 2 shared Akiko ShimamuraiD· 1 shared Annick Raas‐RothschildiD· 1 shared Bertrand BoissoniD· 1 shared Chien-Hsiung Yu· 1 shared Chien‐Hsiung YuiD· 1 shared Chrissie Lim· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Bruno ReversadeORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

DPP9 deficiency: an inflammasomopathy which can be rescued by lowering NLRP1/IL-1 signaling

Cassandra R. Harapas, Kim S. Robinson, Kenneth Lay, Jasmine Wong, Ricardo Moreno Traspas, Nasrin Nabavizadeh, Annick Raas‐Rothschild, Bertrand Boisson, Scott B. Drutman, Pawat Laohamonthonkul, Devon E. Bonner, Jingwei Rachel Xiong, Mark D. Gorrell, Sophia Davidson, Chien‐Hsiung Yu, , Bruno Reversade

This study identifies DPP9 deficiency as a Mendelian disorder causing inflammasome hyperactivity, which can be rescued by reducing NLRP1/IL-1 signaling in mice.

Science Immunology · Sep 16, 2022Peer-reviewedGenetic & Genomic Medicine

DPP9 is an endogenous and direct inhibitor of the NLRP1 inflammasome that guards against human auto-inflammatory diseases

Franklin L. Zhong, Kim Robinson, Chrissie Lim, Cassandra R. Harapas, Chien-Hsiung Yu, William Xie, Radoslaw M. Sobota, Veonice Bijin Au, Richard Hopkins, John E. Connolly, Seth Masters, Bruno Reversade

This study identifies DPP9 as an endogenous inhibitor of the NLRP1 inflammasome, showing its role in preventing auto-inflammatory diseases through regulation of NLRP1 activity.

bioRxiv · Feb 7, 2018 · PreprintImmunology