Copper impedes calcification of human aortic vascular smooth muscle cells through inhibition of osteogenic transdifferentiation and promotion of extracellular matrix stability
Iurii A. Orlov, Gaëlle Lenglet, Carine Avondo, John H. Beattie, Saı̈d Kamel, Irina L. Korichneva
This study shows that physiological copper levels reduce vascular calcification in human aortic VSMCs by inhibiting osteogenic transdifferentiation and stabilizing the extracellular matrix.
Journal of Cellular Physiology · Apr 1, 2025Peer-reviewedBiochemistry