A cargo receptor entrapment complex is a therapeutic node for genetically and clinically distinct proteinopathies
Magdalena Riedl Khursigara, Alissa C. Goss, Maria Kost‐Alimova, Keith H. Keller, Christine Danielle De Mata, Ranjithmenon Muraleedharan, Edward Ryan Collantes, Matthew Brown, Elizabeth J. Grinkevich, Felichi Mae Arines, John Lin, Patrick Byrne, Silvana Bazúa‐Valenti, Elizabeth Morici, Julie Roignot, , Anna Greka
This study identifies a therapeutic target, the entrapment complex, that clears toxic protein accumulation in distinct proteinopathies by disrupting a cargo receptor complex.
bioRxiv · Jul 13, 2026 · PreprintCell Biology