Upscaling production of immunogenic poliovirus virus-like particles in Pichia Pastoris by controlled fermentation
Lee Sherry, Keith Grehan, Mohammad W. Bahar, Jessica J. Swanson, Helen Fox, Sue Matthews, Sarah Carlyle, Ling Qin, Claudine Porta, Steven Wilkinson, Suzanne Robb, Naomi Clark, John M. Liddell, Elizabeth E. Fry, David Ian Stuart, , Nicola J. Stonehouse
This study produces immunogenic poliovirus virus-like particles (VLPs) in Pichia pastoris through controlled fermentation, showing improved immunogenicity compared to current IPV vaccines.
npj Vaccines · Mar 31, 2025Peer-reviewedMicrobiology