Nicola J. Stonehouse

This paper develops trans-encapsidation assays to study enterovirus entry, uncoating, and replication using reporter replicons and structural proteins expressed in trans.

This study identifies interactions between FMDV 2C protein and viral and host factors, revealing ER-derived replication complexes and potential targets for disrupting the FMDV lifecycle.

This study produces immunogenic poliovirus virus-like particles (VLPs) in Pichia pastoris through controlled fermentation, showing improved immunogenicity compared to current IPV vaccines.

The paper describes a modified nanoparticle vaccine platform, N-VelcroVax, which effectively binds SUMO-tagged antigens and shows potential as a vaccine scaffold.

This study produces stabilized poliovirus VLPs using recombinant systems, showing equivalent or better immunogenicity than current vaccines.

This study identifies the pseudoknot region and poly-(C) tract as essential RNA packaging signals for foot-and-mouth disease virus (FMDV) assembly, showing that their length and interactions influence packaging efficiency.

The paper determines the molecular mechanism of VP0 cleavage in enteroviruses using structural and bioinformatic analysis of a provirion intermediate.

This study investigates the role of the conserved S fragment in FMDV replication using SHAPE and genomic analyses, revealing its structural importance and interaction with 3Dpol.

The paper introduces a method to distinguish viral RNA strands and investigates the role of cis-acting elements in FMDV replication.

This study shows that RNA pseudoknots in FMDV are not required for genome replication but are essential for producing infectious virus.