John R Edwards

MIGS: Methylation Interpolated Gene Signatures Determine Associations Between Differential Methylation and Gene Expression

The paper introduces MIGS, a model that uses methylation data to predict gene expression changes, showing it outperforms existing methods and identifies methylation regions most predictive of expression changes.

Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer

The paper identifies epigenetic activation of PTGER4 as a mechanism promoting resistance to aromatase inhibitors in breast cancer and suggests it as a potential therapeutic target.