Unifying population structure and relatedness analysis through a coalescent approach
Diego M. Véliz-Otani, Víctor Borda, Heinner Guio, Omar Cáceres, Cesar Sanchez, Carlos Padilla, Eimear E. Kenny, Sebastian K. Zöllner, Timothy D. O’Connor
This paper introduces a coalescent-based framework to unify population structure and relatedness analysis, showing that full GRMs can replace PCs for modeling genetic covariance.
bioRxiv · Oct 16, 2025 · PreprintGenetics