Acellular normothermic spleen perfusion resolves transcriptional and non-transcriptional mechanisms of steroid immunosuppression
Nicholas A. Callais, Shawn Welch, Randall R Rainwater, John Schaller, Shuoqiu Deng, Ana Clara P. Azevedo‐Pouly, Marie Burdine, Lyle Burdine
An acellular spleen perfusion platform enables serial multiomic sampling to identify steroid-responsive transcriptional programs, validate SOCS3 protein induction, and nominate a non-transcriptional immunosuppressive axis.
bioRxiv · May 19, 2026 · PreprintBioengineering