Author

Ana Clara P. Azevedo‐Pouly

Arkansas Children's Research InstituteORCID 0000-0001-8308-9271Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Marie Burdine· 3 shared Aaron J. StoreyiD· 2 shared Lyle J. BurdineiD· 2 shared Nicholas A. CallaisiD· 2 shared Randall R RainwateriD· 2 shared Zachary J. WaldripiD· 2 shared Belle H. Hicks· 1 shared Brian S. KossiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBioengineering

Marie Burdine

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Acellular normothermic spleen perfusion resolves transcriptional and non-transcriptional mechanisms of steroid immunosuppression

Nicholas A. Callais, Shawn Welch, Randall R Rainwater, John Schaller, Shuoqiu Deng, Ana Clara P. Azevedo‐Pouly, Marie Burdine, Lyle Burdine

An acellular spleen perfusion platform enables serial multiomic sampling to identify steroid-responsive transcriptional programs, validate SOCS3 protein induction, and nominate a non-transcriptional immunosuppressive axis.

bioRxiv · May 19, 2026 · PreprintBioengineering

DNA-PKcs governs LAT-dependent signaling in CD4+ and CD8+ T cells

Randall R Rainwater, Ana Clara P. Azevedo‐Pouly, Zachary J. Waldrip, Belle H. Hicks, Nicholas A. Callais, Brian S. Koss, Aaron J. Storey, Lyle J. Burdine, Marie Burdine

This study shows DNA-PKcs interacts with LAT at the immune synapse, phosphorylates specific serines, and is essential for T cell function in tumor control and graft rejection.

bioRxiv · Mar 6, 2025 · PreprintImmunology

DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells

Zachary J. Waldrip, Lyle J. Burdine, David K. Harrison, Ana Clara P. Azevedo‐Pouly, Aaron J. Storey, Olivia G. Moffett, Samuel G. Mackintosh, Marie Burdine

The paper identifies DNA-PKcs as a kinase that phosphorylates Egr1 at S301, stabilizing it and enhancing IL2 transcription in T cells during activation.

Journal of Biological Chemistry · Sep 22, 2021Peer-reviewedMolecular Biology