Sex-Dependent Effects of Creatine Hydrochloride on Neuroinflammation, Neuronal Survival, and Inhibitory Synaptic Remodeling Following Traumatic Brain Injury in Mice.
Johnny W. Zigmond, Benjamin G. Lamberty, Gretchen J Simon, Johathan M Wood, Natalie M. Elliott, Don W Miller, Kelly L. Stauch
This study investigates the neuroprotective effects of Creatine Hydrochloride (C-HCl) on traumatic brain injury (TBI) in mice, finding sex-dependent benefits in reducing neuroinflammation, neurodegeneration, and inhibitory synaptic remodeling.
bioRxiv · Oct 22, 2026 · PreprintNeuroscience