Weining Chen

Integrative Proteomic Analysis Implicates Inhibition of Intracellular Protein Trafficking in Therapy-Induced Migrastasis in Prostate Cancer

This paper uses proteomic analysis to show that KBU2046 induces migrastasis in prostate cancer by inhibiting intracellular protein trafficking and altering signaling dynamics.

A New Class of Precision Therapeutics that Inhibit Prostate Cancer Mediated Bone Destruction

This paper develops BTE-EN1, a compound that inhibits prostate cancer-mediated bone destruction by targeting cell motility and osteoclast activity, showing efficacy in mice.

Protein Structure Inspired Drug Discovery

The paper uses protein 3D structure analysis to discover novel anticancer compounds by targeting unique structural motifs, identifying Dxr2-017 as a selective inhibitor of melanoma cells.

Predicting the prognosis of non-small cell lung cancer by integrating microarray and clinical data with deep learning

This paper develops a deep learning model integrating microarray and clinical data to predict NSCLC prognosis with high accuracy.