Key residues in SARS-CoV-2 NSP3 hyper variable region are necessary to modulate early stress granule activity.
R. Elias Alvarado, Kumari G. Lokugamage, Dimitriya Hristoforova Garvanska, Leah K. Estes, Yani P. Ahearn, Alyssa M. McLeland, Arian Moayyed, Jennifer C. Chen, Blanca Lopez Mendez, Jessica A. Plante, Kenneth S. Plante, Johnson Bh, Jakob Nilsson, Vineet D. Menachery
This study identifies key residues in SARS-CoV-2 NSP3 that are critical for FXR1 binding and stress granule disruption, showing their role in viral replication and pathogenesis.
Journal of Virology · Jan 14, 2026Peer-reviewedMicrobiology