Blanca Lopez Mendez

This study benchmarks DSF across labs, showing variability in thermal stability parameters due to instruments, workflows, and fluorescence readouts, with harmonization and centralized analysis improving consistency.

The paper systematically assesses the function of short linear motifs (SLiMs) by mutating and screening them in human cells, identifying essential SLiMs for cell proliferation and uncovering novel classes and binding partners.

This study identifies key residues in SARS-CoV-2 NSP3 that are critical for FXR1 binding and stress granule disruption, showing their role in viral replication and pathogenesis.

The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.

The paper develops a proteomics method to identify drug targets across the proteome, revealing organ-specific interactions and global drug effects.

This paper identifies VCF1 as a novel p97 cofactor that enhances p97-UFD1-NPL4 interactions with ubiquitylated substrates, promoting proteasomal degradation.