Jessica A. Plante

This study identifies the molecular basis of chikungunya virus recognition of the mosquito-specific receptor Lachesin using cryo-EM structures and shows a Lachesin polymorphism that blocks virus entry.

This study identifies Lachesin as a mosquito receptor for multiple arthritogenic alphaviruses using CRISPR screening in Aedes albopictus cells.

This study shows that disrupting both NSP3 and nucleocapsid SG antagonism reduces SARS-CoV-2 replication and disease, suggesting stress granule activation as a therapeutic target.

This study identifies key residues in SARS-CoV-2 NSP3 that are critical for FXR1 binding and stress granule disruption, showing their role in viral replication and pathogenesis.

This study shows that the furin cleavage site (FCS) is essential for SARS-CoV-2 pathogenesis but not for transmission, as a mutant lacking FCS was transmissible in hamsters but caused less severe disease.

This study develops mRNA-LNPs encoding neutralizing antibodies against SARS-CoV-2, showing protection against the Omicron variant in mouse and hamster models.

The paper identifies receptor-binding polymorphisms in WEEV that explain shifts in receptor dependencies and enable nonpathogenic strains to infect neurons.

This paper describes a bacteriophage T4-based nanoparticle platform for designing dual COVID-19-Flu mucosal vaccines, showing robust immune responses and protection in mice.

The paper shows that prior immunity to dengue and Zika viruses reduces yellow fever viremia, limiting mosquito infection and urban transmission risk.

Tiled-ClickSeq enables complete SARS-CoV-2 genome sequencing with detection of RNA recombination and minority variants in a single assay.