Hypoxia versus immune depletion - immune profiling and treatment cessation provide mechanistic insights and considerations for translation in Leigh syndrome
Elizaveta A. Olkhova, Ernst‐Bernhard Kayser, Anastasia Dimitriou, Mulholland Michael, Holly Coulson, Vivian Truong, Owen Cairns, Katerina James, Johnson M Brittany, Monika Winter, Vandana Kalia, Surojit Sarkar, Allison Rose Hanaford, Simon C. Johnson
This study investigates the effects of hypoxia and immune interventions in a mouse model of Leigh syndrome, showing that immune cell depletion suppresses disease and hypoxia cessation accelerates disease onset.
bioRxiv · Aug 19, 2026 · PreprintPathology