Vandana Kalia

The paper investigates the role of TLR signaling in Leigh syndrome using a mouse model and finds that MyD88 deficiency modestly improves disease outcomes, while enrofloxacin treatment accelerates disease progression.

This study investigates the effects of hypoxia and immune interventions in a mouse model of Leigh syndrome, showing that immune cell depletion suppresses disease and hypoxia cessation accelerates disease onset.

This study investigates how SARS-CoV-2 S1 protein induces systemic immune responses and long-term anxiety-like behaviors in mice.

This study presents a CRISPR-Cas9-based method to delete genes in primary murine CD8 T cells to assess their functional roles in immune responses and cancer.

This study shows miR-17~92 promotes T cell proliferation and effector differentiation by regulating metabolic pathways like glycolysis and mTOR activation in viral antigen-specific CD4 and CD8 T cells.

This study identifies Treg-mediated suppression of CD4 T cells and inflammatory myeloid cells as critical for metabolic remodeling of CD8 T cells during the effector-to-memory transition.

This study examines how a Treg-selective IL-2 mutein affects influenza-specific T cell responses, showing opposing effects based on administration timing.

This paper describes a designed IL-21 mimic, 21h10, which shows potent antitumor activity in multiple models and reduces toxicity through TNF blockade.