Steric shielding of the KRAS4B hypervariable region enables isoform-specific inhibition of prenylation
Jonas N. Maskos, Yvonne Stark, Valentin Rohner, Andri Häfliger, Dorothea Winkelvoß, Kari Kopra, Peer R. E. Mittl, Andreas Plückthun
This paper develops a dArmRP that selectively shields the KRAS4B hypervariable region, blocking prenylation and reducing membrane localization without affecting other KRAS isoforms.
bioRxiv · Mar 20, 2026 · PreprintBiochemistry