BiochemistrybioRxivPreprint
Steric shielding of the KRAS4B hypervariable region enables isoform-specific inhibition of prenylation
Jonas N. Maskos, Yvonne Stark, Valentin Rohner…·Andreas Plückthun
This paper develops a dArmRP that selectively shields the KRAS4B hypervariable region, blocking prenylation and reducing membrane localization without affecting other KRAS isoforms.
DOI 10.64898/2026.03.18.712636