Dynamic dysregulation of Tenascin-X/Tenascin-C balance controlled by Transforming Growth Factor-beta leads to tumor cell proliferation during pancreatic carcinogenesis
Sophie Liot, Céline Schmitter, Perrine Mercier‐Gouy, Naïma El Kholti, Jonathan Balas, Laura Prigent, Alexandre Aubert, Claire Lethias, Jessica L. Chitty, Manuel Koch, Tanguy Fenouil, Thomas R. Cox, Anà Hennino, Valérie Hervieu, Sylvie Ricard‐Blum, , Elise Lambert
This study shows that the balance between TNX and TNC, controlled by TGF-β, affects tumor cell proliferation in pancreatic cancer, suggesting TNX as a potential therapeutic target.
bioRxiv · Feb 7, 2025 · PreprintCancer Biology