Tanguy Fenouil

This study identifies cDC1 and cDC2 as essential for TGF-β activation and pTreg induction in the gut, maintaining immune tolerance.

This study identifies ribosome biogenesis as a therapeutic vulnerability in TNBC, showing that inhibiting rRNA maturation via Fibrillarin or RNA Pol I reduces tumor growth without significant cell death.

The paper investigates how the developmental lineage of medulloblastoma cells influences their behavior in an avian embryo model, finding that G3 tumors use SLIT signaling linked to aggressiveness.

This study shows that the balance between TNX and TNC, controlled by TGF-β, affects tumor cell proliferation in pancreatic cancer, suggesting TNX as a potential therapeutic target.

The paper shows 5-FU induces translational reprogramming in colorectal cancer cells, enhancing drug tolerance through pro-tumoral gene expression and IL-8 overexpression.